|Title||Passive functional mapping of receptive language cortex during general anesthesia using electrocorticography.|
|Publication Type||Journal Article|
|Year of Publication||2023|
|Authors||Nourmohammadi, A, Swift, JR, de Pesters, A, Guay, CS, Adamo, MA, Dalfino, JC, Ritaccio, AL, Schalk, G, Brunner, P|
|Keywords||Anesthesia, General, Brain, Brain Mapping, Cerebral Cortex, Electrocorticography, Humans, Language|
OBJECTIVE: To investigate the feasibility of passive functional mapping in the receptive language cortex during general anesthesia using electrocorticographic (ECoG) signals.
METHODS: We used subdurally placed ECoG grids to record cortical responses to speech stimuli during awake and anesthesia conditions. We identified the cortical areas with significant responses to the stimuli using the spectro-temporal consistency of the brain signal in the broadband gamma (BBG) frequency band (70-170 Hz).
RESULTS: We found that ECoG BBG responses during general anesthesia effectively identify cortical regions associated with receptive language function. Our analyses demonstrated that the ability to identify receptive language cortex varies across different states and depths of anesthesia. We confirmed these results by comparing them to receptive language areas identified during the awake condition. Quantification of these results demonstrated an average sensitivity and specificity of passive language mapping during general anesthesia to be 49±7.7% and 100%, respectively.
CONCLUSION: Our results demonstrate that mapping receptive language cortex in patients during general anesthesia is feasible.
SIGNIFICANCE: Our proposed protocol could greatly expand the population of patients that can benefit from passive language mapping techniques, and could eliminate the risks associated with electrocortical stimulation during an awake craniotomy.
|Alternate Journal||Clin Neurophysiol|
|PubMed Central ID||PMC10267852|
|Grant List||U24 NS109103 / NS / NINDS NIH HHS / United States |
U01 NS108916 / NS / NINDS NIH HHS / United States
U01 NS128612 / NS / NINDS NIH HHS / United States
R01 EB026439 / EB / NIBIB NIH HHS / United States
P50 MH109429 / MH / NIMH NIH HHS / United States
P41 EB018783 / EB / NIBIB NIH HHS / United States