|Title||Potential differences between monolingual and bilingual patients in approach and outcome after awake brain surgery.|
|Publication Type||Journal Article|
|Year of Publication||2020|
|Authors||ReFaey, K, Tripathi, S, Bhargav, AG, Grewal, SS, Middlebrooks, EH, Sabsevitz, DS, Jentoft, M, Brunner, P, Wu, A, Tatum, WO, Ritaccio, A, Chaichana, KL, Quinones-Hinojosa, A|
|Keywords||Brain Mapping, Brain Neoplasms, Craniotomy, Female, Follow-Up Studies, Glioma, Humans, Incidence, Language, Male, Middle Aged, Monitoring, Intraoperative, Prognosis, Retrospective Studies, Seizures, United States, Wakefulness|
INTRODUCTION: 20.8% of the United States population and 67% of the European population speak two or more languages. Intraoperative different languages, mapping, and localization are crucial. This investigation aims to address three questions between BL and ML patients: (1) Are there differences in complications (i.e. seizures) and DECS techniques during intra-operative brain mapping? (2) Is EOR different? and (3) Are there differences in the recovery pattern post-surgery?
METHODS: Data from 56 patients that underwent left-sided awake craniotomy for tumors infiltrating possible dominant hemisphere language areas from September 2016 to June 2019 were identified and analyzed in this study; 14 BL and 42 ML control patients. Patient demographics, education level, and the age of language acquisition were documented and evaluated. fMRI was performed on all participants.
RESULTS: 0 (0%) BL and 3 (7%) ML experienced intraoperative seizures (P = 0.73). BL patients received a higher direct DECS current in comparison to the ML patients (average = 4.7, 3.8, respectively, P = 0.03). The extent of resection was higher in ML patients in comparison to the BL patients (80.9 vs. 64.8, respectively, P = 0.04). The post-operative KPS scores were higher in BL patients in comparison to ML patients (84.3, 77.4, respectively, P = 0.03). BL showed lower drop in post-operative KPS in comparison to ML patients (- 4.3, - 8.7, respectively, P = 0.03).
CONCLUSION: We show that BL patients have a lower incidence of intra-operative seizures, lower EOR, higher post-operative KPS and tolerate higher DECS current, in comparison to ML patients.
|Alternate Journal||J Neurooncol|
|PubMed Central ID||PMC7968692|
|Grant List||R01 CA216855 / CA / NCI NIH HHS / United States |
R01 CA195503 / CA / NCI NIH HHS / United States
U24 NS109103 / NS / NINDS NIH HHS / United States
U01 NS108916 / NS / NINDS NIH HHS / United States
R01 EB026439 / EB / NIBIB NIH HHS / United States
P41 EB018783 / EB / NIBIB NIH HHS / United States
R43 CA221490 / CA / NCI NIH HHS / United States
R01 CA200399 / CA / NCI NIH HHS / United States