%0 Journal Article %J Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale %D 1989 %T Operant conditioning of primate triceps surae H-reflex produces reflex asymmetry. %A Jonathan Wolpaw %A Lee, C. L. %A Calaitges, J. G. %K Learning %K Memory %K monosynaptic reflex %K operant conditioning %K plasticity %K Spinal Cord %K spinal reflex %X Monkeys are able to increase or decrease triceps surae H-reflex when reward depends on reflex amplitude. Operantly conditioned change occurs over weeks and produces persistent alterations in the lumbosacral spinal cord which should be technically accessible substrates of primate memory. Previous work monitored and conditioned triceps surae H-reflex in one leg. To determine whether H-reflex conditioning in one leg affects the control leg, the present study monitored H-reflexes in both legs while the reflex in one leg underwent HR increases or HR decreases conditioning. Under the HR increases mode, H-reflex increase was much greater in the HR increases leg than in the control leg. Under the HR decreases mode, H-reflex decrease was confined to the HR decreases leg. By showing that conditioning of one leg's H-reflex produces H-reflex asymmetry, the data further define the phenomenon and indicate that the other leg can serve as an internal control for physiologic and anatomic studies exploring the sites and mechanisms of the spinal cord memory substrates. %B Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale %V 75 %P 35–39 %8 03/1989 %G eng %U http://www.ncbi.nlm.nih.gov/pubmed/2707354 %R 10.1007/BF00248527 %0 Journal Article %J Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale %D 1987 %T Motoneuron response to dorsal root stimulation in anesthetized monkeys after spinal cord transection. %A Jonathan Wolpaw %A Lee, C. L. %K monosynaptic reflex %K primate %K Spinal Cord %K spinal cord injury %K spinal reflex %K spinal shock %X In preparation for studying the spinal cord alterations produced by operant conditioning of spinal reflexes, we studied peripheral nerve responses to supramaximal dorsal root stimulation in the lumbosacral cord of deeply anesthetized monkeys before and after thoracic cord transection. Except for variable depression in the first few minutes, reflex responses were not reduced or otherwise significantly affected by transection in the hour immediately following the lesion or for at least 50 h. The results suggest that reduction in muscle spindle sensitivity and/or in polysynaptic motoneuron excitation contributes to stretch reflex depression after cord transection. %B Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale %V 68 %P 428–433 %8 10/1987 %G eng %U http://www.ncbi.nlm.nih.gov/pubmed/3480233 %R 10.1007/BF00248809