TY - JOUR T1 - Analysis of the correlation between local field potentials and neuronal firing rate in the motor cortex. JF - Conf Proc IEEE Eng Med Biol Soc Y1 - 2006 A1 - Wang, Yiwen A1 - Sanchez, Justin C A1 - Principe, Jose A1 - Mitzelfelt, Jeremiah D A1 - Gunduz, Aysegul KW - Action Potentials KW - Animals KW - Brain KW - Brain Mapping KW - Electric Stimulation KW - Electrodes KW - Evoked Potentials, Motor KW - Male KW - Models, Statistical KW - Motor Cortex KW - Neurons KW - Rats KW - Rats, Sprague-Dawley KW - Signal Processing, Computer-Assisted KW - Synaptic Transmission AB -

Neuronal firing rate has been the signal of choice for invasive motor brain machine interfaces (BMI). The use of local field potentials (LFP) in BMI experiments may provide additional dendritic information about movement intent and may improve performance. Here we study the time-varying amplitude modulated relationship between local field potentials (LFP) and single unit activity (SUA) in the motor cortex. We record LFP and SUA in the primary motor cortex of rats trained to perform a lever pressing task, and evaluate the correlation between pairs of peri-event time histograms (PETH) and movement evoked local field potentials (mEP) at the same electrode. Three different correlation coefficients were calculated and compared between the neuronal PETH and the magnitude and power of the mEP. Correlation as high as 0.7 for some neurons occurred between the PETH and the mEP magnitude. As expected, the correlations between the single trial LFP and SUV are much lower due to the inherent variability of both signals.

VL - 1 UR - http://www.ncbi.nlm.nih.gov/pubmed/17946745 ER -