02948nas a2200445   4500008004100000022001400041245008900055210006900144260001200213300001000225490000900235520165000244653002501894653001201919653002201931653001001953653002001963653002701983653002702010653003802037653001102075653002602086653004002112653000902152653000902161653002302170653002902193653003602222653002502258653002902283653001702312653002202329100001702351700001702368700001102385700001602396700002502412700001702437856004802454       2013                        eng d  a1872-624000aNovel inter-hemispheric white matter connectivity in the BTBR mouse model of autism.0 aNovel interhemispheric white matter connectivity in the BTBR mou  c06/2013  a26-330 v15133 aAlterations in the volume, density, connectivity and functional activation of white matter tracts are reported in some individuals with autism and may contribute to their abnormal behaviors. The BTBR (BTBR T+tf/J) inbred strain of mouse, is used to model facets of autism because they develop low social behaviors, stereotypical and immune changes similar to those found in people with autism. Previously, it was thought a total absence of corpus callosal interhemispheric connective tissues in the BTBR mice may underlie their abnormal behaviors. However, postnatal lesions of the corpus callosum do not precipitate social behavioral problems in other strains of mice suggesting a flaw in this theory. In this study we used digital pathological methods to compare subcortical white matter connective tracts in the BTBR strain of mice with those found in the C57Bl/6 mouse and those reported in a standardized mouse brain atlas. We report, for the first time, a novel connective subcortical interhemispheric bridge of tissue in the posterior, but not anterior, cerebrum of the BTBR mouse. These novel connective tissues are comprised of myelinated fibers, with reduced myelin basic protein levels (MBP) compared to levels in the C57Bl/6 mouse. We used electrophysiological analysis and found increased inter-hemispheric connectivity in the posterior hemispheres of the BTBR strain compared with the anterior hemispheres. The conduction velocity was slower than that reported in normal mice. This study shows there is novel abnormal interhemispheric connectivity in the BTBR strain of mice, which may contribute to their behavioral abnormalities.10aAnalysis of Variance10aAnimals10aAutistic Disorder10aBrain10aCorpus Callosum10aDisease Models, Animal10aElectroencephalography10aEnzyme-Linked Immunosorbent Assay10aFemale10aFunctional Laterality10aImage Processing, Computer-Assisted10aMale10aMice10aMice, Inbred C57BL10aMice, Neurologic Mutants10aMicrotubule-Associated Proteins10aMyelin Basic Protein10aNerve Fibers, Myelinated10aNeuroimaging10aSpectrum Analysis1 aMiller, V, M1 aGupta, Disha1 aNeu, N1 aCotroneo, A1 aBoulay, Chadwick, B.1 aSeegal, R, F  uhttp://www.ncbi.nlm.nih.gov/pubmed/23570707