02491nas a2200229   4500008004100000022001400041245013500055210006900190260000900259300001200268490000600280520167600286100002301962700001801985700003402003700002102037700002102058700001902079700002702098700001802125856011802143       2024                        eng d  a2632-129700aThe involvement of the piriform cortex in non-lesional temporal lobe epilepsy: an uncommon component of the epileptogenic network.0 ainvolvement of the piriform cortex in nonlesional temporal lobe   c2024  afcae1790 v63 a<p>The piriform cortex is recognized as highly epileptogenic in rodents, yet its electrophysiological role in human epilepsy remains understudied. Recent surgical outcomes have suggested potential benefits in resecting the piriform cortex for cases of medial temporal lobe epilepsy. However, little is known about its electrophysiological activity in human epilepsy. This case-series study aimed to explore the electrophysiological role of the piriform cortex within the epileptogenic network among patients with suspected temporal lobe epilepsy. Participants were recruited from Emory University Hospital or Children's Healthcare of Atlanta, with non-lesional frontotemporal or temporal lobe hypotheses, undergoing stereoelectroencephalographic studies. Specifically, focus was placed on patients with one or more electrode contacts in the piriform cortex. Primary objectives included determining piriform cortex involvement within the electrophysiologically defined epileptogenic network and assessing the effects of electrical stimulation. Twenty-two patients were included in the study. Notably, only one patient exhibited piriform cortex involvement at seizure onset, associated with an olfactory aura. Two patients showed early piriform cortex involvement, while others displayed late or no involvement. Electrical stimulation of the piriform cortex induced after-discharges in three patients and replicated a habitual seizure in one. These findings present a contrast to surgical outcome studies, suggesting that the piriform cortex may not typically play a significant role in the epileptogenic network among patients with non-lesional temporal lobe epilepsy.</p>1 aPedersen, Nigel, P1 aRaghu, Ashley1 aShivamurthy, Veeresh, Kumar N1 aChern, Joshua, J1 aGross, Robert, E1 aWillie, Jon, T1 aDingledine, Raymond, J1 aKheder, Ammar  uhttps://www.neurotechcenter.org/publications/2024/involvement-piriform-cortex-non-lesional-temporal-lobe-epilepsy