02321nas a2200253 4500008004100000022001400041245011300055210006900168260001200237520148500249100001301734700001401747700001901761700001801780700002101798700001801819700001801837700001701855700001801872700001901890700001901909700001601928856012301944 2022 eng d a1741-255200aAutomated intraoperative central sulcus localization and somatotopic mapping using median nerve stimulation.0 aAutomated intraoperative central sulcus localization and somatot c07/20223 a

OBJECTIVE: Accurate identiļ¬cation of functional cortical regions is essential in neurological resection. The central sulcus (CS) is an important landmark that delineates functional cortical regions. Median nerve stimulation (MNS) is a standard procedure to identify the position of the CS intraoperatively. In this paper, we introduce an automated procedure that uses MNS to rapidly localize the CS and create functional somatotopic maps.

APPROACH: We recorded electrocorticographic signals from 13 patients who underwent MNS in the course of an awake craniotomy. We analyzed these signals to develop an automated procedure that determines the location of the CS and that also produces functional somatotopic maps.

MAIN RESULTS: The comparison between our automated method and visual inspection performed by the neurosurgeon shows that our procedure has a high sensitivity (89%) in identifying the CS. Further, we found substantial concordance between the functional somatotopic maps generated by our method and passive functional mapping (92% sensitivity).

SIGNIFICANCE: Our automated MNS-based method can rapidly localize the CS and create functional somatotopic maps without imposing additional burden on the clinical procedure. With additional development and validation, our method may lead to a diagnostic tool that guides neurosurgeon and reduces postoperative morbidity in patients undergoing resective brain surgery.

1 aXie, Tao1 aWu, Zehan1 aSchalk, Gerwin1 aTong, Yusheng1 aVato, Alessandro1 aRaviv, Nataly1 aGuo, Qinglong1 aYe, Huanpeng1 aSheng, Xinjun1 aZhu, Xiangyang1 aBrunner, Peter1 aChen, Liang uhttps://www.neurotechcenter.org/publications/2022/automated-intraoperative-central-sulcus-localization-and-somatotopic