01127nas a2200241   4500008004100000022001400041245003400055210003300089260001200122300001000134490000700144520043600151653005800587653001100645653002900656653002100685653002600706653002000732653003700752100002600789700002200815856004800837       2010                        eng d  a1469-182500aSymptoms as latent variables.0 aSymptoms as latent variables  c06/2010  a165-60 v333 aIn the target article, Cramer et al. suggest that diagnostic classification is improved by modeling the relationship between manifest variables (i.e., symptoms) rather than modeling unobservable latent variables (i.e., diagnostic categories such as Generalized Anxiety Disorder). This commentary discusses whether symptoms represent manifest or latent variables and the implications of this distinction for diagnosis and treatment.10aDiagnostic and Statistical Manual of Mental Disorders10aHumans10aInterview, Psychological10aMental Disorders10aModels, Psychological10aSleep Disorders10aStress Disorders, Post-Traumatic1 aMcFarland, Dennis, J.1 aMalta, Loretta, S  uhttp://www.ncbi.nlm.nih.gov/pubmed/20584384