01639nas a2200169   4500008004100000022001400041245007900055210006900134260001200203300001400215490000700229520113600236653001301372100002101385700001801406856004501424       1978                        eng d  a0013-469400aEffects of ethanol, caffeine, and placebo on the auditory evoked response.0 aEffects of ethanol caffeine and placebo on the auditory evoked r  c05/1978  a568–5740 v443 aA previous paper (Wolpaw and Penry 1975) described separation of the 75-250 msec portion of the AER into N1P2, a product of large areas of cortex, and the T complex, probably a product of secondary auditory cortex. With monaural stimulation, the T complex is larger and earlier on the side contralateral to stimulation and on the right side. Thirty-one normal adults received 3 oz. of ethanol, 300 mg of caffeine, or placebo. Monaural AERs were recorded before intake in all cases, 1 and 4 h after ethanol and 80 min after caffeine or placebo. Blood levels of ethanol and caffeine were measured. Placebo produced mild (20%) decreases in N1P2 amplitude. Caffeine did not decrease N1P2 amplitude. It did produce a statistically significant 2% decrease in Ta peak latency. Ethanol reduced N1P2 amplitude markedly at 1 h and mildly at 4 h. Placebo did not affect hemispheric differences. Caffeine significantly increased the Ta peak ipsilateral vs. contralateral latency difference in 3 of 7 individuals. Ethanol significantly increased it in 3 of 6 subjects at 1 h and in 7 of 10 at 4 h, primarily by increasing ipsilateral latencies.10aPlacebos1 aWolpaw, Jonathan1 aPenry, J., K.  uhttp://www.ncbi.nlm.nih.gov/pubmed/77763