01790nas a2200229   4500008004100000022001400041245005800055210005600113260001200169300001200181490000800193520117500201653001301376653002501389653001501414653000801429653001801437653001601455100002101471700002101492856004701513       1996                        eng d  a0014-481900aReversal of H-reflex operant conditioning in the rat.0 aReversal of Hreflex operant conditioning in the rat  c11/1996  a58–620 v1123 aIn response to an operant conditioning task, rats can gradually increase or decrease soleus H-reflex amplitude without change in background electromyographic activity or M response amplitude. Both increase (under the HRup mode) and decrease (under the HRdown mode) develop over weeks. The present study investigated reversal of conditioned H-reflex change. Following collection of control data, rats were exposed to one mode (HRup or HRdown) for 50 days, and then exposed to the opposite mode for up to 72 days. Rats responded to each mode exposure with gradual, mode-appropriate change in H-reflex amplitude. This finding is consistent with other evidence that H-reflex conditioning depends on spinal cord plasticity. The effects of exposure to the HRup (or HRdown) mode were not affected by whether exposure followed previous exposure to the HRdown (or HRup) mode. In accord with recent studies suggesting that HRup and HRdown conditioning have different spinal mechanisms, these results suggest that reversal of H-reflex change is due primarily to the superimposition of additional plasticity rather than to decay of the plasticity responsible for the initial change.10aH-Reflex10aoperant conditioning10aplasticity10arat10asoleus muscle10aSpinal Cord1 aChen, Xiang Yang1 aWolpaw, Jonathan  uhttp://www.ncbi.nlm.nih.gov/pubmed/8951407