@article {3157, title = {Conduction velocity is inversely related to action potential threshold in rat motoneuron axons.}, journal = {Experimental brain research. Experimentelle Hirnforschung. Exp{\'e}rimentation c{\'e}r{\'e}brale}, volume = {150}, year = {2003}, month = {06/2003}, pages = {497{\textendash}505}, abstract = {Intra-axonal recordings were performed in ventral roots of rats in vitro to study the conduction velocity and firing threshold properties of motoneuron axons. Mean values +/- SD were 30.5+/-5.6 m/s for conduction velocity and 11.6+/-4.5 mV for the depolarization from the resting potential required to reach firing threshold (threshold depolarization). Conduction velocity varied inversely and significantly with threshold depolarization ( P=0.0002 by linear regression). This relationship was evident even after accounting for variation in conduction velocity associated with action potential amplitude, injected current amplitude, or body weight. Conduction velocity also varied inversely with the time to action potential onset during just-threshold current pulse injection. These data suggest that the time course of depolarization leading to action potential initiation contributes to the speed of conduction in motoneuron axons.}, keywords = {action potential, conduction velocity, intra-axonal recording, myelinated axon, threshold}, issn = {0014-4819}, doi = {10.1007/s00221-003-1475-8}, url = {http://www.ncbi.nlm.nih.gov/pubmed/12715118}, author = {Jonathan S. Carp and Tennissen, Ann M. and Jonathan Wolpaw} }