@article {4583,
	title = {A novel theta-controlled vibrotactile brain-computer interface to treat chronic pain: a pilot study.},
	journal = {Sci Rep},
	volume = {14},
	year = {2024},
	month = {2024 Feb 10},
	pages = {3433},
	abstract = {<p>Limitations in chronic pain therapies necessitate novel interventions that are effective, accessible, and safe. Brain-computer interfaces (BCIs) provide a promising modality for targeting neuropathology underlying chronic pain by converting recorded neural activity into perceivable outputs. Recent evidence suggests that increased frontal theta power (4-7~Hz) reflects pain relief from chronic and acute pain. Further studies have suggested that vibrotactile stimulation decreases pain intensity in experimental and clinical models. This longitudinal, non-randomized, open-label pilot study{\textquoteright}s objective was to reinforce frontal theta activity in six patients with chronic upper extremity pain using a novel vibrotactile neurofeedback BCI system. Patients increased their BCI performance, reflecting thought-driven control of neurofeedback, and showed a significant decrease in pain severity (1.29 {\textpm} 0.25 MAD, p = 0.03, q = 0.05) and pain interference (1.79 {\textpm} 1.10 MAD p = 0.03, q = 0.05) scores without any adverse events. Pain relief significantly correlated with frontal theta modulation. These findings highlight the potential of BCI-mediated cortico-sensory coupling of frontal theta with vibrotactile stimulation for alleviating chronic pain.</p>},
	keywords = {brain-computer interfaces, Chronic Pain, Electroencephalography, Humans, Longitudinal Studies, Neurofeedback, Non-Randomized Controlled Trials as Topic, Pilot Projects},
	issn = {2045-2322},
	doi = {10.1038/s41598-024-53261-3},
	author = {Demarest, Phillip and Rustamov, Nabi and Swift, James and Xie, Tao and Adamek, Markus and Cho, Hohyun and Wilson, Elizabeth and Han, Zhuangyu and Belsten, Alexander and Luczak, Nicholas and Brunner, Peter and Haroutounian, Simon and Leuthardt, Eric C}
}
@article {4557,
	title = {A novel theta-controlled vibrotactile brain{\textendash}computer interface to treat chronic pain: a pilot study},
	journal = {Scientific reports},
	volume = {14},
	year = {2024},
	pages = {3433},
	author = {Demarest, Phillip and Rustamov, Nabi and Swift, James and Xie, Tao and Adamek, Markus and Cho, Hohyun and Wilson, Elizabeth and Han, Zhuangyu and Belsten, Alexander and Luczak, Nicholas and others}
}
@article {4447,
	title = {Toward a fully implantable ecosystem for adaptive neuromodulation in humans: Preliminary experience with the CorTec BrainInterchange device in a canine model.},
	journal = {Front Neurosci},
	volume = {16},
	year = {2022},
	month = {12/2022},
	pages = {932782},
	abstract = {<p>This article describes initial work toward an ecosystem for adaptive neuromodulation in humans by documenting the experience of implanting CorTec{\textquoteright}s BrainInterchange (BIC) device in a beagle canine and using the BCI2000 environment to interact with the BIC device. It begins with laying out the substantial opportunity presented by a useful, easy-to-use, and widely available hardware/software ecosystem in the current landscape of the field of adaptive neuromodulation, and then describes experience with implantation, software integration, and post-surgical validation of recording of brain signals and implant parameters. Initial experience suggests that the hardware capabilities of the BIC device are fully supported by BCI2000, and that the BIC/BCI2000 device can record and process brain signals during free behavior. With further development and validation, the BIC/BCI2000 ecosystem could become an important tool for research into new adaptive neuromodulation protocols in humans.</p>},
	issn = {1662-4548},
	doi = {10.3389/fnins.2022.932782},
	author = {Schalk, Gerwin and Worrell, Samuel and Mivalt, Filip and Belsten, Alexander and Kim, Inyong and Morris, Jonathan M and Hermes, Dora and Klassen, Bryan T and Staff, Nathan P and Messina, Steven and Kaufmann, Timothy and Rickert, J{\"o}rn and Brunner, Peter and Worrell, Gregory A and Miller, Kai J}
}
