@article {3390,
	title = {Locomotor impact of beneficial or nonbeneficial H-reflex conditioning after spinal cord injury.},
	journal = {J Neurophysiol},
	volume = {111},
	year = {2014},
	month = {03/2014},
	pages = {1249-58},
	abstract = {When new motor learning changes neurons and synapses in the spinal cord, it may affect previously learned behaviors that depend on the same spinal neurons and synapses. To explore these effects, we used operant conditioning to strengthen or weaken the right soleus H-reflex pathway in rats in which a right spinal cord contusion had impaired locomotion. When up-conditioning increased the H-reflex, locomotion improved. Steps became longer, and step-cycle asymmetry (i.e., limping) disappeared. In contrast, when down-conditioning decreased the H-reflex, locomotion did not worsen. Steps did not become shorter, and asymmetry did not increase. Electromyographic and kinematic analyses explained how H-reflex increase improved locomotion and why H-reflex decrease did not further impair it. Although the impact of up-conditioning or down-conditioning on the H-reflex pathway was still present during locomotion, only up-conditioning affected the soleus locomotor burst. Additionally, compensatory plasticity apparently prevented the weaker H-reflex pathway caused by down-conditioning from weakening the locomotor burst and further impairing locomotion. The results support the hypothesis that the state of the spinal cord is a "negotiated equilibrium" that serves all the behaviors that depend on it. When new learning changes the spinal cord, old behaviors undergo concurrent relearning that preserves or improves their key features. Thus, if an old behavior has been impaired by trauma or disease, spinal reflex conditioning, by changing a specific pathway and triggering a new negotiation, may enable recovery beyond that achieved simply by practicing the old behavior. Spinal reflex conditioning protocols might complement other neurorehabilitation methods and enhance recovery.},
	keywords = {Animals, Conditioning, Operant, Female, H-Reflex, Learning, Locomotion, Male, Rats, Rats, Sprague-Dawley, Spinal Cord Injuries},
	issn = {1522-1598},
	doi = {10.1152/jn.00756.2013},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/24371288},
	author = {Yi Chen and Lu Chen and Liu, Rongliang and Wang, Yu and Xiang Yang Chen and Jonathan Wolpaw}
}
@article {3383,
	title = {Persistent beneficial impact of H-reflex conditioning in spinal cord-injured rats.},
	journal = {J Neurophysiol},
	volume = {112},
	year = {2014},
	month = {11/2014},
	pages = {2374-81},
	abstract = {<p>Operant conditioning of a spinal cord reflex can improve locomotion in rats and humans with incomplete spinal cord injury. This study examined the persistence of its beneficial effects. In rats in which a right lateral column contusion injury had produced asymmetric locomotion, up-conditioning of the right soleus H-reflex eliminated the asymmetry while down-conditioning had no effect. After the 50-day conditioning period ended, the H-reflex was monitored for 100 [{\textpm}9 (SD)] (range 79-108) more days and locomotion was then reevaluated. After conditioning ended in up-conditioned rats, the H-reflex continued to increase, and locomotion continued to improve. In down-conditioned rats, the H-reflex decrease gradually disappeared after conditioning ended, and locomotion at the end of data collection remained as impaired as it had been before and immediately after down-conditioning. The persistence (and further progression) of H-reflex increase but not H-reflex decrease in these spinal cord-injured rats is consistent with the fact that up-conditioning improved their locomotion while down-conditioning did not. That is, even after up-conditioning ended, the up-conditioned H-reflex pathway remained adaptive because it improved locomotion. The persistence and further enhancement of the locomotor improvement indicates that spinal reflex conditioning protocols might supplement current therapies and enhance neurorehabilitation. They may be especially useful when significant spinal cord regeneration becomes possible and precise methods for retraining the regenerated spinal cord are needed.</p>},
	keywords = {H-reflex conditioning, Learning, Locomotion, Memory, Motor control, Rehabilitation, spinal cord injury, spinal cord plasticity},
	issn = {1522-1598},
	doi = {10.1152/jn.00422.2014},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/25143542},
	author = {Yi Chen and Lu Chen and Wang, Yu and Jonathan Wolpaw and Xiang Yang Chen}
}
@article {3100,
	title = {Reflex conditioning: a new strategy for improving motor function after spinal cord injury.},
	journal = {Annals of the New York Academy of Sciences},
	volume = {1198 Suppl 1},
	year = {2010},
	month = {06/2010},
	pages = {E12{\textendash}E21},
	abstract = {Spinal reflex conditioning changes reflex size, induces spinal cord plasticity, and modifies locomotion. Appropriate reflex conditioning can improve walking in rats after spinal cord injury (SCI). Reflex conditioning offers a new therapeutic strategy for restoring function in people with SCI. This approach can address the specific deficits of individuals with SCI by targeting specific reflex pathways for increased or decreased responsiveness. In addition, once clinically significant regeneration can be achieved, reflex conditioning could provide a means of reeducating the newly (and probably imperfectly) reconnected spinal cord.},
	keywords = {H-Reflex, learning and memory, Locomotion, plasticity, reflex conditioning, Rehabilitation, spinal cord injury},
	issn = {1749-6632},
	doi = {10.1111/j.1749-6632.2010.05565.x},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/20590534},
	author = {Xiang Yang Chen and Yi Chen and Wang, Yu and Thompson, Aiko and Jonathan S. Carp and Segal, Richard L. and Jonathan Wolpaw}
}
