@article {3199, title = {A P300-based brain-computer interface for people with amyotrophic lateral sclerosis.}, journal = {Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology}, volume = {119}, year = {2008}, month = {08/2008}, pages = {1909{\textendash}1916}, abstract = {OBJECTIVE: The current study evaluates the efficacy of a P300-based brain-computer interface (BCI) communication device for individuals with advanced ALS. METHODS: Participants attended to one cell of a N x N matrix while the N rows and N columns flashed randomly. Each cell of the matrix contained one character. Every flash of an attended character served as a rare event in an oddball sequence and elicited a P300 response. Classification coefficients derived using a stepwise linear discriminant function were applied to the data after each set of flashes. The character receiving the highest discriminant score was presented as feedback. RESULTS: In Phase I, six participants used a 6 x 6 matrix on 12 separate days with a mean rate of 1.2 selections/min and mean online and offline accuracies of 62\% and 82\%, respectively. In Phase II, four participants used either a 6 x 6 or a 7 x 7 matrix to produce novel and spontaneous statements with a mean online rate of 2.1 selections/min and online accuracy of 79\%. The amplitude and latency of the P300 remained stable over 40 weeks. CONCLUSIONS: Participants could communicate with the P300-based BCI and performance was stable over many months. SIGNIFICANCE: BCIs could provide an alternative communication and control technology in the daily lives of people severely disabled by ALS.}, keywords = {Amyotrophic Lateral Sclerosis, brain-computer interface, electroencephalogram, event-related potentials, P300, Rehabilitation}, issn = {1388-2457}, doi = {10.1016/j.clinph.2008.03.034}, url = {http://www.ncbi.nlm.nih.gov/pubmed/18571984}, author = {Nijboer, F. and Sellers, E. W. and Mellinger, J. and Jordan, M. A. and Matuz, T. and Adrian Furdea and S Halder and Mochty, U. and Krusienski, D. J. and Theresa M Vaughan and Jonathan Wolpaw and Niels Birbaumer and K{\"u}bler, A.} } @inbook {2139, title = {Brain Computer Interfaces for Communication in Paralysis: a Clinical-Experimental Approach.}, year = {2007}, publisher = {Virtual Library of Psychology at Saarland University and State Library, GERMANY, PsyDok [http://psydok.sulb.uni-saarland.de/phpoai/oai2.php] (Germany)}, organization = {Virtual Library of Psychology at Saarland University and State Library, GERMANY, PsyDok [http://psydok.sulb.uni-saarland.de/phpoai/oai2.php] (Germany)}, abstract = {

An overview of different approaches to brain-computer interfaces (BCIs) developed in our laboratory is given. An important clinical application of BCIs is to enable communication or environmental control in severely paralyzed patients. The BCI {\textquotedblleft}Thought-Translation Device (TTD){\textquotedblright} allows verbal communication through the voluntary self-regulation of brain signals (e.g., slow cortical potentials (SCPs)), which is achieved by operant feedback training. Humans{\textquoteright} ability to self-regulate their SCPs is used to move a cursor toward a target that contains a selectable letter set. Two different approaches were followed to developWeb browsers that could be controlled with binary brain responses. Implementing more powerful classification methods including different signal parameters such as oscillatory features improved our BCI considerably. It was also tested on signals with implanted electrodes. Most BCIs provide the user with a visual feedback interface. Visually impaired patients require an auditory feedback mode. A procedure using auditory (sonified) feedback of multiple EEG parameters was evaluated. Properties of the auditory systems are reported and the results of two experiments with auditory feedback are presented. Clinical data of eight ALS patients demonstrated that all patients were able to acquire efficient brain control of one of the three available BCI systems (SCP, {\textmu}-rhythm, and P300), most of them used the SCP-BCI. A controlled comparison of the three systems in a group of ALS patients, however, showed that P300-BCI and the {\textmu}-BCI are faster and more easily acquired than SCP-BCI, at least in patients with some rudimentary motor control left. Six patients who started BCI training after entering the completely locked-in state did not achieve reliable communication skills with any BCI system. One completely locked-in patient was able t o communicate shortly with a ph-meter, but lost control afterward.

}, keywords = {brain-computer interfaces, EEG, experiment, Medical sciences Medicine, paralyzed patients, slow cortical potentials, Thought-Translation Device}, isbn = {9780262256049}, url = {http://psydok.sulb.uni-saarland.de/volltexte/2008/2154/}, author = {Hinterberger, T. and Nijboer, F and K{\"u}bler, A. and Matuz, T. and Adrian Furdea and Mochty, Ursula and Jordan, M. and Lal, T.N and Jeremy Jeremy Hill and Mellinger, J{\"u}rgen and Bensch, M and Tangermann, Michael and Widmann, G. and Elger, Christian and Rosenstiel, W. and Sch{\"o}lkopf, B and Niels Birbaumer} }