Ablation of the inferior olive prevents H-reflex down-conditioning in rats.

TitleAblation of the inferior olive prevents H-reflex down-conditioning in rats.
Publication TypeJournal Article
Year of Publication2016
AuthorsChen, XY, Wang, Y, Chen, Y, Chen, L, Wolpaw, JR
JournalJournal of neurophysiology
Volume115
Pagination1630–1636
Date PublishedMar
ISSN1522-1598
KeywordsSpinal Cord
Abstract

We evaluated the role of the inferior olive (IO) in acquisition of the spinal cord plasticity that underlies H-reflex down-conditioning, a simple motor skill. The IO was chemically ablated before a 50-day exposure to an operant conditioning protocol that rewarded a smaller soleus H-reflex. In normal rats, down-conditioning succeeds (i.e., H-reflex size decreases at least 20%) in 80% of animals. Down-conditioning failed in every IO-ablated rat (P

URLhttp://www.ncbi.nlm.nih.gov/pubmed/26792888
DOI10.1152/jn.01069.2015

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