Current Collaborative Projects



Dr. Aiko Thompson Robust Spinal Reflex Conditioning System
Dr. Kathleen Friel Reflex Conditioning in Cerebral Palsy
Dr. David Reinkensmeyer Stroke BCI-Based EEG Rehabilitation
Dr. Ellyn Riley BCI-Based Aphasia Rehabilitation
Dr. James Morizio Wireless Reflex Conditioning System
Dr. Robert Knight Decoding the Prefrontal Cortex
Dr. Nancy Kanwisher Cortical Connectivity by DTI and Stimulation



Robust Spinal Reflex Conditioning System

Dr. Aiko Thompson, Medical University of South Carolina

The long-term goal of this ongoing collaborative project is to enhance the clinical efficacy and efficiency of spinal reflex operant conditioning protocols and accelerate their translation into clinical use. It combines NCAN’s unique expertise in reflex conditioning technology with the Medical University of South Carolina's (MUSC’s) unique experience in clinical use of this technology and strong capacity to test the suitability of new reflex conditioning systems for use by clinical therapists. The aim of the collaboration is to develop, optimize, and validate a robust general-purpose operant conditioning system suitable for clinical use. NCAN will develop algorithms that support complex protocols (e.g., allowing conditioning during a dynamic behavior such as locomotion), facilitate selection of recording and stimulating sites and parameters for a broad range of responses, configure the accompanying stimulation/recording hardware, and produce associated fully integrated instructions. The system with all of its components will be tested, optimized, and validated through push-pull interactions with MUSC, where it will be used by groups of physical therapy students and the results will be assessed by the data provided and by feedback from the users.
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Reflex Conditioning in Cerebral Palsy

Dr. Kathleen Friel, Burke Neurological Institute

This collaborative project will explore the efficacy of spinal reflex operant conditioning for reducing spasticity and improving motor functions in adults and children with cerebral palsy (CP). These individuals constitute a large and otherwise healthy population that frequently suffers from disabling spasticity. If spinal reflex conditioning proves efficacious in reducing this problem, it would be an important therapeutic advance. We have two collaborative aims:

1. To investigate the efficacy of spinal reflex conditioning for reducing spasticity in adults and children with cerebral palsy. We will determine the impact of H-reflex down-conditioning on the soleus H-reflex over 30 conditioning sessions and over subsequent months. We will also assess the associated effects on locomotor speed, symmetry, kinematics, and EMG; on clinical measures of spasticity; and on participant reports of their functioning in daily life. We will compare the data gathered before the conditioning sessions, with those gathered at the end of conditioning and 3 months later. This initial study will incorporate an appropriate control group who complete a comparable protocol that does not include H-reflex down-conditioning.

2. To evaluate the impact of spinal reflex conditioning on corticospinal function. For the participants studied in Aim 1, we will use transcranial magnetic stimulation (TMS) to detect and map the changes in cortical control over spinal cord motoneuron populations associated with spinal reflex conditioning. These data will be gathered before the conditioning sessions, after their completion, and 3 months later. We hypothesize that H-reflex decrease and functional improvements will be associated with stronger corticospinal control that will be evident as increases in the motor evoked potentials (MEPs) produced by TMS.
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Stroke BCI-Based EEG Rehabilitation

Dr. David Reinkensmeyer, University of California, Irvine

This collaborative project is optimizing and validating pre-movement BCI-based EEG sensorimotor-rhythm (SMR) amplitude training as a new method for enhancing recovery of useful motor function in people with strokes that have impaired hand/arm function. If it is successful, it will provide a new therapy that could complement current therapies and augment recovery of useful motor function. We have two collaborative aims:

1. To confirm and extend our preliminary study indicating that BCI-based training to control pre-movement sensorimotor rhythm (SMR) amplitude can improve finger extension in people with moderate to severe hand impairment due to chronic stroke. Using quantitative clinical measures, we will determine the time course, magnitude, consistency, and persistence of this beneficial impact.

2. To determine whether BCI-based training to increase pre-movement cortico-muscular coupling can enhance functional recovery after stroke. Cortico-muscular coherence reflects functional coupling between cortex and muscles; thus, its increase is likely to be associated with increased cortical control and improved motor function. Using quantitative clinical measures, we will determine the time course, magnitude, consistency, and persistence of any beneficial impact that occurs.
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BCI-Based Aphasia Rehabilitation

Dr. Ellyn Riley, Syracuse University

This recently launched collaborative project addresses the need for new therapeutic methods that can enhance language recovery for people afflicted with aphasia after stroke. Recent studies indicate that errorless learning protocols can improve performance during treatment sessions but not necessarily beyond; retrieval practice may be important for effecting long-term improvement. Previous results and a preliminary study (Riley and McFarland, 2017) suggested that EEG-based BCI technology might be able to combine the virtues of errorless learning and retrieval practice to enhance language recovery. With this as our goal, we have two collaborative aims:

1. To establish that EEG features can predict naming errors and error correction in people with aphasia due to stroke. Encouraged by our initial study (Riley and McFarland, 2017), we will use a new paradigm that asks participants to name famous people; it supports studies in those with or without aphasia. Repeated testing enables evaluation of the consistency of retrieval. We expect to find that EEG features in the alpha (8-12 Hz) and/or beta (18-30 Hz) frequency range can predict errors and error correction.

2. Based on the results of the first collaborative aim, we will then design a paradigm that uses these selected EEG features to enhance aphasia therapy. First, subject-specific EEG features that predict naming success will be identified. Next, we will incorporate a brief pulse of transcranial alternating current stimulation (tACS) in naming trials in which the participant-specific EEG features associated with successful naming are not present; tACS frequency and location will be based on the frequency and scalp topography of these EEG features.
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Wireless Reflex Conditioning System

Dr. James Morizio, Triangle BioSystems International (TBSI)

In this new Collaborative Project with Dr. James Morizio at TBSI, we will develop an implantable telemetry-based turnkey system for small laboratory animals that supports long-term 24/7 interactions with the CNS that can target plasticity to specific CNS pathways and thereby modify sensorimotor function. The basis for this turnkey-system will be the existing TBSI recording and stimulation hardware (Fan et al., 2011; Li et al., 2017) and NCAN’s general-purpose BCI2000 software platform (Schalk et al., 2004; Schalk and Mellinger, 2010; Brunner and Schalk, 2018). We will improve the system capabilities of the TBSI hardware and of the BCI2000 software; integrate the TBSI hardware with the BCI2000 software to create a robust, easy-to-use, and highly flexible laboratory system; and create and disseminate use-case demonstrations for neuromodulation and operant conditioning based on this new TBSI-BCI2000 laboratory system.
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Decoding the Prefrontal Cortex

Dr. Robert Knight, University of California, Berkeley

The long-term goal of this collaborative project is to improve the understanding of prefrontal cortex (PFC) function by combining NCAN’s unique technologies to characterize and modify cortical function with UCB’s sophisticated neuroscientific understanding of the PFC. We will use our new stimulation methods to study the influence of the PFC in goal-directed behavior. The collaborative aims are:

1. To test the hypothesis that interactions between PFC and posterior cortical regions are causally related to categorical perception.

2. To test the hypothesis that electrical stimulation of cortical processes in PFC that underlie categorical perception produces persistent changes on a millimeter scale.

To accomplish these collaborative aims, UCB will study subjects with ECoG recording arrays that cover PFC and also cover auditory and/or visual cortical areas. They will collect ECoG data while the subjects perform auditory and/or visual categorical perception tasks. Through two series of push-pull interactions (one for each collaborative aim), UCB and NCAN will test the hypotheses that interactions between PFC and posterior regions are causally responsible for categorical perception (Aim 1), and that changes to cortical processes in PFC resulting from electrical stimulation are functionally heterogeneous on a millimeter scale (Aim 2).
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Cortical Connectivity by DTI and Stimulation

Nancy Kanwisher, MIT

Through this Collaborative Project with Dr. Kanwisher at MIT, we will apply the new stimulation device developed in TR&D2 and applied to human subjects in TR&D3 to enable Dr. Kanwisher to study the relationship between connectivity established using electrical stimulation and connectivity derived by diffusion tensor imaging (DTI). We will collect DTI data at Albany Medical College, and will scan a subset of those subjects at the Connectome scanner at MGH in Boston (one of only two in the world and optimized specifically for DTI imaging). This project will drive technology development for ECoG stimulation that induces short-term changes in network activity. The push-pull interactions between NCAN and MIT detailed here will achieve the collaborative aim to correlate the connections defined by electrical stimulation to the connections defined by DTI.

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