@article {3420, title = {A general framework for dynamic cortical function: the function-through-biased-oscillations (FBO) hypothesis.}, journal = {Front. Hum. Neurosci.}, volume = {9}, year = {2015}, month = {06/2015}, abstract = {A central goal of neuroscience is to determine how the brain{\textquoteright}s relatively static anatomy can support dynamic cortical function, i.e., cortical function that varies according to task demands. In pursuit of this goal, scientists have produced a large number of experimental results and established influential conceptual frameworks, in particular communication-through-coherence (CTC) and gating-by-inhibition (GBI), but these data and frameworks have not provided a parsimonious view of the principles that underlie cortical function. Here I synthesize these existing experimental results and the CTC and GBI frameworks, and propose the function-through-biased-oscillations (FBO) hypothesis as a model to understand dynamic cortical function. The FBO hypothesis suggests that oscillatory voltage amplitude is the principal measurement that directly reflects cortical excitability, that asymmetries in voltage amplitude explain a range of brain signal phenomena, and that predictive variations in such asymmetric oscillations provide a simple and general model for information routing that can help to explain dynamic cortical function.}, keywords = {communication-through-coherence, gating-by-inhibition, information routing, oscillations, oscillatory modulation}, doi = {10.3389/fnhum.2015.00352}, url = {http://journal.frontiersin.org/article/10.3389/fnhum.2015.00352/abstract}, author = {Gerwin Schalk} }